Pressor and Renal Hemodynamic Effects of the Novel Angiotensin A Peptide Are Angiotensin II Type 1A Receptor Dependent
Identifieur interne : 006805 ( Main/Exploration ); précédent : 006804; suivant : 006806Pressor and Renal Hemodynamic Effects of the Novel Angiotensin A Peptide Are Angiotensin II Type 1A Receptor Dependent
Auteurs : RUI YANG [Belgique] ; Ilse Smolders [Belgique] ; Patrick Vanderheyden [Belgique] ; Heidi Demaegdt [Belgique] ; Ann Van Eeckhaut [Belgique] ; Georges Vauquelin [Belgique] ; Aneta Lukaszuk [Belgique] ; Dirk Tourwe [Belgique] ; Siew Yeen Chai [Australie] ; Anthony L. Albiston [Australie] ; Clara Nahmias [France] ; Thomas Walther [Royaume-Uni] ; Alain G. Dupont [Belgique, Allemagne]Source :
- Hypertension : (Dallas, Tex. 1979) [ 0194-911X ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Recently, a new derivative of angiotensin (Ang) II, called "Ang A," has been discovered to be present in plasma of healthy humans and, in increased concentrations, in end-stage renal failure patients. The objectives of the study were to investigate the blood pressure and renal hemodynamic responses to Ang A in normotensive and hypertensive rats and in genetically modified mice and the binding properties of Ang A to Ang II type 1 (AT,) or Ang II type 2 (AT2) receptors. Intravenous and intrarenal administration of Ang A induced dose-dependent pressor and renal vasoconstrictor responses in normotensive rats, which were blocked by the AT1 receptor antagonist candesartan but were not altered by the AT2 receptor ligands PD123319, CGP42112A, or compound 21. Similar responses were observed after intravenous administration in spontaneously hypertensive rats. Deletion of AT1a receptors in mice almost completely abolished the pressor and renal vasoconstrictor responses to Ang A, indicating that its effects are mediated via AT1a receptors. Ang A was less potent than Ang II in vivo. The in vitro study demonstrated that Ang A is a full agonist for AT1 receptors, with similar affinity for AT1 and AT2 receptors as Ang II. Overall, the responses to Ang A and Ang II were similar. Ang A has no physiological role to modulate the pressor and renal hemodynamic effects of Ang II.
Affiliations:
- Allemagne, Australie, Belgique, France, Royaume-Uni
- Région de Bruxelles-Capitale, Victoria (État), Île-de-France
- Bruxelles, Melbourne, Paris
- Université de Melbourne
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aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Smolders, Ilse" sort="Smolders, Ilse" uniqKey="Smolders I" first="Ilse" last="Smolders">Ilse Smolders</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Vanderheyden, Patrick" sort="Vanderheyden, Patrick" uniqKey="Vanderheyden P" first="Patrick" last="Vanderheyden">Patrick Vanderheyden</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Demaegdt, Heidi" sort="Demaegdt, Heidi" uniqKey="Demaegdt H" first="Heidi" last="Demaegdt">Heidi Demaegdt</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Van Eeckhaut, Ann" sort="Van Eeckhaut, Ann" uniqKey="Van Eeckhaut A" first="Ann" last="Van Eeckhaut">Ann Van Eeckhaut</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Vauquelin, Georges" sort="Vauquelin, Georges" uniqKey="Vauquelin G" first="Georges" last="Vauquelin">Georges Vauquelin</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Lukaszuk, Aneta" sort="Lukaszuk, Aneta" uniqKey="Lukaszuk A" first="Aneta" last="Lukaszuk">Aneta Lukaszuk</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Organic Chemistry, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Tourwe, Dirk" sort="Tourwe, Dirk" uniqKey="Tourwe D" first="Dirk" last="Tourwe">Dirk Tourwe</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Organic Chemistry, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Yeen Chai, Siew" sort="Yeen Chai, Siew" uniqKey="Yeen Chai S" first="Siew" last="Yeen Chai">Siew Yeen Chai</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Physiology, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Albiston, Anthony L" sort="Albiston, Anthony L" uniqKey="Albiston A" first="Anthony L." last="Albiston">Anthony L. Albiston</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Neuropeptides Group, Howard Florey Institute, University of Melbourne</s1><s2>Parkville, Melbourne</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Nahmias, Clara" sort="Nahmias, Clara" uniqKey="Nahmias C" first="Clara" last="Nahmias">Clara Nahmias</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Institut National de la Sante et de la Recherche Medicale U1016, Institut Cochin</s1><s2>Paris</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre National de la Recherche Scientifique , UMR8104</s1><s2>Paris</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>University Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Walther, Thomas" sort="Walther, Thomas" uniqKey="Walther T" first="Thomas" last="Walther">Thomas Walther</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre for Biomedical Research, Hull York Medical School, University of Hull</s1><s2>Hull, Yorkshire</s2><s3>GBR</s3><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Hull, Yorkshire</wicri:noRegion></affiliation></author><author><name sortKey="Dupont, Alain G" sort="Dupont, Alain G" uniqKey="Dupont A" first="Alain G." last="Dupont">Alain G. Dupont</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Departments of Pharmacology, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department Experimental Cardiology , Excellence Cluster Cardio-Pulmonary System, Justus-Liebig-Universitat Giessen</s1><s2>Giessen</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Justus-Liebig-Universitat Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Hypertension : (Dallas, Tex. 1979)</title><title level="j" type="abbreviated">Hypertension : (Dallas Tex., 1979)</title><idno type="ISSN">0194-911X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Hypertension : (Dallas, Tex. 1979)</title><title level="j" type="abbreviated">Hypertension : (Dallas Tex., 1979)</title><idno type="ISSN">0194-911X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiotensin II</term><term>Arterial pressure</term><term>Blood flow</term><term>Blood pressure</term><term>Cardiovascular disease</term><term>Hemodynamics</term><term>Hypertension</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Hémodynamique</term><term>Angiotensine II</term><term>Débit sanguin</term><term>Pression artérielle</term><term>Pression sanguine</term><term>Hypertension artérielle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, a new derivative of angiotensin (Ang) II, called "Ang A," has been discovered to be present in plasma of healthy humans and, in increased concentrations, in end-stage renal failure patients. The objectives of the study were to investigate the blood pressure and renal hemodynamic responses to Ang A in normotensive and hypertensive rats and in genetically modified mice and the binding properties of Ang A to Ang II type 1 (AT,) or Ang II type 2 (AT<sub>2</sub>) receptors. Intravenous and intrarenal administration of Ang A induced dose-dependent pressor and renal vasoconstrictor responses in normotensive rats, which were blocked by the AT<sub>1</sub> receptor antagonist candesartan but were not altered by the AT<sub>2</sub> receptor ligands PD123319, CGP42112A, or compound 21. Similar responses were observed after intravenous administration in spontaneously hypertensive rats. Deletion of AT<sub>1a</sub> receptors in mice almost completely abolished the pressor and renal vasoconstrictor responses to Ang A, indicating that its effects are mediated via AT<sub>1a</sub> receptors. Ang A was less potent than Ang II in vivo. The in vitro study demonstrated that Ang A is a full agonist for AT<sub>1</sub> receptors, with similar affinity for AT<sub>1</sub> and AT<sub>2</sub> receptors as Ang II. Overall, the responses to Ang A and Ang II were similar. Ang A has no physiological role to modulate the pressor and renal hemodynamic effects of Ang II.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Royaume-Uni</li></country><region><li>Région de Bruxelles-Capitale</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Rui Yang" sort="Rui Yang" uniqKey="Rui Yang" last="Rui Yang">RUI YANG</name></region><name sortKey="Demaegdt, Heidi" sort="Demaegdt, Heidi" uniqKey="Demaegdt H" first="Heidi" last="Demaegdt">Heidi Demaegdt</name><name sortKey="Dupont, Alain G" sort="Dupont, Alain G" uniqKey="Dupont A" first="Alain G." last="Dupont">Alain G. Dupont</name><name sortKey="Lukaszuk, Aneta" sort="Lukaszuk, Aneta" uniqKey="Lukaszuk A" first="Aneta" last="Lukaszuk">Aneta Lukaszuk</name><name sortKey="Rui Yang" sort="Rui Yang" uniqKey="Rui Yang" last="Rui Yang">RUI YANG</name><name sortKey="Smolders, Ilse" sort="Smolders, Ilse" uniqKey="Smolders I" first="Ilse" last="Smolders">Ilse Smolders</name><name sortKey="Tourwe, Dirk" sort="Tourwe, Dirk" uniqKey="Tourwe D" first="Dirk" last="Tourwe">Dirk Tourwe</name><name sortKey="Van Eeckhaut, Ann" sort="Van Eeckhaut, Ann" uniqKey="Van Eeckhaut A" first="Ann" last="Van Eeckhaut">Ann Van Eeckhaut</name><name sortKey="Vanderheyden, Patrick" sort="Vanderheyden, Patrick" uniqKey="Vanderheyden P" first="Patrick" last="Vanderheyden">Patrick Vanderheyden</name><name sortKey="Vauquelin, Georges" sort="Vauquelin, Georges" uniqKey="Vauquelin G" first="Georges" last="Vauquelin">Georges Vauquelin</name></country><country name="Australie"><noRegion><name sortKey="Yeen Chai, Siew" sort="Yeen Chai, Siew" uniqKey="Yeen Chai S" first="Siew" last="Yeen Chai">Siew Yeen Chai</name></noRegion><name sortKey="Albiston, Anthony L" sort="Albiston, Anthony L" uniqKey="Albiston A" first="Anthony L." last="Albiston">Anthony L. Albiston</name></country><country name="France"><region name="Île-de-France"><name sortKey="Nahmias, Clara" sort="Nahmias, Clara" uniqKey="Nahmias C" first="Clara" last="Nahmias">Clara Nahmias</name></region><name sortKey="Nahmias, Clara" sort="Nahmias, Clara" uniqKey="Nahmias C" first="Clara" last="Nahmias">Clara Nahmias</name><name sortKey="Nahmias, Clara" sort="Nahmias, Clara" uniqKey="Nahmias C" first="Clara" last="Nahmias">Clara Nahmias</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Walther, Thomas" sort="Walther, Thomas" uniqKey="Walther T" first="Thomas" last="Walther">Thomas Walther</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Dupont, Alain G" sort="Dupont, Alain G" uniqKey="Dupont A" first="Alain G." last="Dupont">Alain G. Dupont</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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